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Xymogen S-Acetyl Glutathione 60 Veggie Caps

SKU
A0052475
Non-GMO
Gluten Free
Soy Free
Dairy Free
$86.99
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S-Acetyl Glutathione

  • Provides antioxidants that help reduce the oxidative damage caused by free radicals

Reduced glutathione, commonly known as glutathione or GSH, is a tripeptide consisting of L-glutamine, L-cysteine, and glycine. It is ubiquitous in living systems. Glutathione biosynthesis can be affected by biochemical individuality and/or dietary factors. Chronic oxidative stress can also deplete cellular glutathione. Precursors to glutathione, such as whey protein, vitamin C, and glutamine, are often recommended to boost glutathione levels in the body; however, results are inconsistent. Biological individuality is such that not every body has equivalent ability to metabolize the precursor to raise glutathione.*

Why Not Give Pure Glutathione?

Unfortunately, most oral forms of glutathione are foul smelling, but more importantly, the majority of an oral dose is oxidized before it can be absorbed and used by the cells. This formulation delivers a unique preparation of glutathione that overcomes these usual limitations. The stability of S-acetylglutathione through the intestinal wall and the plasma is well documented in the literature. Oral intake of S-acetylglutathione increases total glutathione and percent-reduced glutathione. Percent-reduced glutathione is a very significant biomarker of health status.*[1-5]

Mechanism of Absorption

S-acetylglutathione, a lipid-like compound, is taken up intact by chylomicrons in the gut. The acetyl bond is placed on its thiol group or sulfur group, which prevents oxidation and allows the molecule to pass diffusively into the cell after absorption in the gut. The bond is then cleaved by non-specific enzymes inside the cell. Acetylation prevents the breakdown of glutathione, and S-acetylglutathione does not require energy expenditure to be cleaved to reduced glutathione once it crosses the cell wall.*[1-8]

Antioxidant Activity

Glutathione functions extensively in tissues and organs throughout the body. It plays critical roles in protecting the body from oxidative stress, maintaining cellular functions, and supporting healthy immune function.[1,4] Many factors can increase cellular exposure to oxidative insult, and therefore increase cellular consumption of nutrients—such as glutathione—that provide antioxidant activity. This may result in a fierce cycle of oxidative stress and challenges to detoxification. Complete biotransformation and protection from oxidative stress are important to maintaining cellular integrity and tissue health.*[2,5]

Other Benefits of Maintaining Healthy Glutathione Levels

Much information related to mitochondrial health has surfaced in the literature. Mitochondria, the energy-producing powerhouses of cells, are also the primary intracellular site of oxygen consumption and the major source of reactive oxygen species (ROS). S-acetylglutathione has been shown to cross the membrane of the mitochondria, increasing the organelle’s activity and minimizing ROS.[8,9] Reduction of ROS is associated with maintaining mitochondrial integrity and function, and improved mitochondrial health is believed to support overall health and energy.

S-acetylglutathione has also been shown to decrease TNF-alpha, NFkappa beta, and F-2 isoprostane.[4,9-12] Additionally, there is mounting evidence that intracellular glutathione levels in antigen-presenting cells (e.g. macrophages) may influence the Th1/Th2 cytokine response pattern and promote a balanced immune reaction.*[10]

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Medicinal Ingredients (per vegetarian capsule)

L-Glutathione (from S-Acetyl Glutathione) ........................................................................................ 100 mg

Non-Medicinal Ingredients

Hypromellose (acid-resistant vegetarian capsule), microcrystalline cellulose, stearic acid, magnesium stearate, silica.

Recommended Dose

Adults: Take one to two capsules one to two times daily or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use if you are pregnant or breastfeeding.

Storage: Keep tightly closed in a cool, dry place out of reach of children. Do not use if tamper
seal is damaged.

Does Not Contain

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Healthy Planet Canada wants to ensure the complete and total accuracy of the product images and information contained on our website. However, some manufacturing changes to packaging or ingredients may be pending updates on our website.

Some items may occasionally ship with alternate packaging (recently updated by the supplier or manufacturer). While in these cases, ingredients are usually the same and only the packaging has been updated, we always recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by Healthy Planet Canada.

Probiotics Disclaimer:

Probiotics are refrigerated in our warehouse to ensure quality and optimal potency. They are also shipped with a FREE ice pack. Although the product may not be cold when it arrives, this ice pack helps maintain a cooler temperature during transit. We recommend considering weekend/holiday delays when ordering (I.E. ordering on a weekday and not on Friday or Saturday, or during holidays