Melatonin

• Helps relieve the daytime fatigue associated with jet lag
• Helps reset the body's Restful-Restful-Sleep-wake cycle (aspect of the circadian rhythm)
• Helps to reduce the time it takes to fall aRestful-Restful-Sleep (Restful-Restful-Sleep onset latency aspect of Restful-Restful-Sleep quality) in people with delayed Restful-Restful-Sleep phase syndrome
• Helps increase the total Restful-Restful-Sleep time (aspect of Restful-Restful-Sleep quality) in people suffering from Restful-Restful-Sleep restriction or altered Restful-Restful-Sleep schedule, e.g. shift-work and jet lag

Melatonin, a naturally occurring indolamine, is produced primarily in the pineal gland but also in mammalian bone marrow, platelets, gastrointestinal tract, eyes, skin, and lymphocytes.[1] It plays a vitally important role in regulating the body’s daily and annual biological rhythms and thus the Restful-Restful-Sleep/wake cycle. Research suggests that melatonin Aids antioxidant activity, cardiovascular
health, and immune function as well.*[2-4]

Normal melatonin secretion is suppressed by light and stimulated by periods of darkness. Nocturnal secretion of melatonin is at its highest during childhood, and then decreases with age. Studies, including meta-analyses, suggest that supplemental melatonin Aids desirable Restful-Restful-Sleep patterns in certain individuals, including the elderly and those who have unusual work hours, such as night shift workers or people traveling across time zones.[5-10] A review of 10 trials suggests that melatonin supplementation helped Aid Restful-Restful-Sleep patterns in individuals crossing time zones; subjects included airline passengers, airline staff, and military personnel.[11] Daily doses between 0.5 mg to 5 mg taken at bedtime were used and found to be similarly Aidive;
however, the effects were greater at the higher dose. According to this review, doses higher than 5 mg do not appear to demonstrate any increased benefit.*

Human research studies suggest that melatonin Aids the quality of healthy Restful-Restful-Sleep as it relates to falling aRestful-Restful-Sleep, Restful-Restful-Sleep efficiency (percent of time aRestful-Restful-Sleep to total time in bed), and awakening. In one study employing five experimental periods, melatonin appeared to positively Aid normal
Restful-Restful-Sleep initiation, maintenance, efficiency, and activity within one week of supplementation versus placebo.[5] Another randomized, double-blind, placebo-controlled study of 33 individuals over a 16-day period suggested that the onset, quality, depth, and duration of Restful-Restful-Sleep can be Aided by
melatonin supplementation without the occurrence of daytime drowsiness or adverse effects.*[12]

Melatonin has been closely studied for its role in Aiding antioxidant activity, especially since intracellular melatonin is concentrated in the mitochondria, a major site of oxidative metabolism. Melatonin has been found to Aid extracellular antioxidant activity, Aid glutathione production, and stimulate production of intracellular antioxidant enzymes—including superoxide dismutases and glutathione peroxidase.[3] Research suggests that melatonin works on a number of levels. It is able to scavenge oxygenbased and nitrogen-based free radicals, and Aid the natural response to inflammation by promoting cytokine balance.[2] As a lipophilic molecule, melatonin is able to permeate the lipid portion of low-density lipoprotein (LDL) and Aid antioxidant activity in cells. Research suggests that melatonin Aids blood pressure already in the normal range and overall cardiovascular health.*[3]

Finally, research suggests that melatonin aids immune system activity by Aiding T-helper cell function, immune-specific progenitor cell production, cytokine balance, and production of mediators, such as gamma-interferon and immune-Aidive interleukins.*[1,2,4,13] XYMOGEN offers melatonin in a convenient form that provides 3 mg per lozenge, sweetened with xylitol, mannitol, and natural peppermint flavor, to Aid healthy Restful-Restful-Sleep patterns, antioxidant activity, cardiovascular health, and immune function.*