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SD Pharmaceuticals’ CITRULLINE MALATE 2000™ is formulated with a scientifically validated dose of pure citrulline malate. Citrulline has been shown in research to play a key role in aerobic and anaerobic pathways of energy metabolism, as well as nitric oxide production, demonstrating its ability to enhance energy, reduce fatigue, and pump muscles up during workouts!
Citrulline is an amino acid that is converted to L-arginine in the body during the urea cycle, alongside the other amino acid L-ornithine. Supplementing with citrulline is a more effective way to raise arginine levels and enhance nitric oxide (NO) production in the body, rather than supplementing with arginine.
Citrulline plays a role in ATP production, increasing energy demands when required while also buffering buildup of ammonia in the muscle, reducing exercise fatigue and increasing workout endurance.
Citrulline malate supplementation has been shown to reduce post-workout muscle soreness for up to 48 hours in trained athletes, while also reducing the sensation and onset of muscle fatigue.
Citrulline can modulate enzymes involved in glycogen breakdown, glycogenolysis, and enzymes that convert glucose to ATP through glycolysis. This action shifts muscle from aerobic to anaerobic metabolism, reducing the rate at which the body uses up ATP and phosphocreatine, while also accelerating their replenishment. This means more energy is available to the muscles for longer working sets, a reduction in muscle fatigue and longer cardio sessions!
Ammonia acts as a signal for muscle fatigue when it accumulates by inhibiting conversion of pyruvate to acetyl-CoA, blocking muscle contraction. Citrulline buffers ammonia, via the urea cycle, increasing ornithine levels, and promoting ureogenesis (production of urea) and bicarbonate reabsorption, which preserves bicarbonate and allows it to perform its buffering action against ammonia.
Citrulline increases plasma levels of L-arginine in a dose-dependent manner. It has been shown that supplementing with citrullinemalate can help increase the levels of L-arginine, which in turn allows for more availability of L-arginine for the NOS pathway of NO production. More NO means greater blood flow and better nutrient delivery to working muscles.
Citrulline may help restore muscle protein synthesis rates and muscular function simply by improving nitrogen balance and encouraging use of amino acids—particularly BCAA in muscles during exercise. Improved nitrogen retention and presence of BCAA helps signal the mTORpathway of protein synthesis.
This antioxidant helps increase the activity of the enzyme nitric oxide synthase, the protein that produces nitric oxide. It also helps sustain NO bioavailability.
CITRULLINE MALATE 2000™ is formulated with the patented absorption complex AstraGin™, which has been clinically shown to significantly improve nutrient absorption, ensuring maximum absorption with every serving of CITRULLINE MALATE 2000™.
Helps the body metabolize fats and proteins. Helps in the development and maintenance of bones, cartilage, teeth and gums. Helps in connective tissue formation and in wound healing. An antioxidant for the maintenance of good health.
1 scoop(s) 1 to 2 time(s) per day. Mix product in 150 – 200 mL of liquid (water, juice, etc.) immediately before consumption.
Consult a health care practitioner for use beyond 3 months.
KEEP OUT OF REACH OF CHILDREN. Not intended for use by persons under the age of 18. Ensure to drink enough fluids before, during and after exercise. Consult a health care practitioner before use if you are pregnant or breast-feeding, have an autoimmune disorder, are taking antidepressant medications, blood thinners or digoxin, or if you have diabetes. Known Adverse Reactions: Some people may experience insomnia, anxiety or headaches, in which case, discontinue use. Store under normal storage conditions (dry, well-ventilated premises at 15-25°C).