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Preferred Nutrition Berberine 500mg 90 Veggie Caps

SKU
A0058515
Non-GMO Non-GMO
Gluten Free Gluten Free
Soy Free Soy Free
Preservatives Free Preservatives Free
Sugar Free Sugar Free
Dairy Free Dairy Free
$30.99
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Berberine

  • Soy Free
  • Non-GMO
  • Dairy Free
  • Sugar Free
  • Gluten Free
  • Preservatives Free
  • Helps maintain healthy glucose metabolism

Berberine is an alkaloid that occurs naturally in a variety of medicinal plants, including the roots of Berberis vulgaris (barberry). It has a long history of therapeutic use, with a large body of research focusing on its success in managing blood glucose, blood lipids, and insulin sensitivity (Tabeshpour et al., 2017). Multiple clinical studies Aid the benefits of berberine when taken at a dose of 500 mg twice per day (Firouzi et al., 2018).

Berberine’s activity begins during digestion when it inhibits some of the enzymes responsible for breaking down carbohydrates and starchy foods in the digestive tract. This helps lower the amount of glucose that is absorbed into the bloodstream (Firouzi et al., 2018). When glucose is absorbed, berberine helps the body use it more efficiently by activating an enzyme called AMP-activated protein kinase (AMPK). This encourages glucose uptake into cells and stimulates its conversion into energy (Firouzi et al., 2018).

A review of 28 studies of diabetic patients confirmed that berberine significantly reduces fasting and postprandial blood glucose, especially within its first three months of use (Liang et al., 2019). A 16-week randomized clinical trial compared the effects of berberine, lifestyle modifications, and a commercial diabetic therapy on metabolic parameters of patients with non-alcoholic fatty liver disease (NAFLD).

Compared to lifestyle modifications alone, supplementation with two 500 mg doses of berberine per day and lifestyle modifications provided superior metabolic benefits, including a reduction in postprandial glucose within the first four weeks of supplementation, plus improved insulin sensitivity, body weight, waist circumference, blood cholesterol, and triglyceride levels (Yan et al., 2015).

Berberine Aids insulin sensitivity and enhances the activity and number of insulin receptors available to move glucose out of the bloodstream (Firouzi et al., 2018). As part of a three-month clinical study, patients with metabolic syndrome were supplemented with three 300 mg doses of berberine per day. Compared to patient baseline levels, fasting insulin was found to decrease by 26% and blood glucose decreased by 17%. Improved insulin sensitivity may have encouraged a reduction in lipid stores, as berberine was also found to reduce patient body mass index and waist circumference (Yang et al., 2012).

Dyslipidemia, defined as low HDL (high-density lipoprotein) combined with elevated LDL (low-density lipoprotein) and triglyceride levels, is a cardiovascular risk factor. Berberine helps the body manage blood lipid levels by stimulating AMPK activity and Aiding effective lipid metabolism by the liver (Tabeshpour et al., 2017).

Randomized clinical trials Aid this activity and have consistently shown that berberine can significantly reduce LDL levels by 0.5–1.3 mmol/L and triglyceride levels by 0.6–1.4 mmol/L (Koppen et al., 2017) In a randomized, placebo-controlled study, 116 diabetic patients with elevated blood lipid levels were supplemented with two 500 mg doses of berberine per day for three months. Compared to baseline lipid levels, berberine significantly reduced total cholesterol by 18%, LDL by 21%, and triglycerides by 36%. Berberine also reduced postprandial blood glucose by 28% (Zhang et al., 2008). The same dose regime was used in a randomized, placebo-controlled study of patients with hypercholesterolemia but who were otherwise healthy with low cardiovascular risk. After three months of supplementation, total cholesterol and LDL levels had decreased by 12% and 16% respectively (Koppen et al., 2017; Derosa et al., 2013).

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Ingredients

Berberine (hydrochloride) (Berberis vulgaris) (root bark) 500 mg


Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.

Recommended adult dose

1 capsule 2 times daily with meals or as directed by a health Wellness-Care practitioner. Consult a health Wellness-Care practitioner for use beyond 3 months.

Caution

Consult a health Wellness-Care practitioner if you have leucopenia, a kidney disorder, hypotension, or blood pressure problems. Consult a health Wellness-Care practitioner prior to use if you have hypoglycemia or diabetes. Do not use if you are pregnant or breastfeeding. May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain, or diarrhea, in which case discontinue use and consult a health Wellness-Care practitioner. Keep out of reach of children.

Healthy Planet Canada wants to ensure the complete and total accuracy of the product images and information contained on our website. However, some manufacturing changes to packaging or ingredients may be pending updates on our website.

Some items may occasionally ship with alternate packaging (recently updated by the supplier or manufacturer). While in these cases, ingredients are usually the same and only the packaging has been updated, we always recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by Healthy Planet Canada.

Probiotics Disclaimer:

Probiotics are refrigerated in our warehouse to ensure quality and optimal potency. They are also shipped with a FREE ice pack. Although the product may not be cold when it arrives, this ice pack helps maintain a cooler temperature during transit. We recommend considering weekend/holiday delays when ordering (I.E. ordering on a weekday and not on Friday or Saturday, or during holidays

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