The proanthocyanidin-rich formula safeguards sensitive tissues and organ systems in the body against disease-causing free radicals.

Grape seed extract, a bioflavonoid abundant in proanthocyanidins, serves the purpose of combating free radicals and supporting capillary health. Its resemblance to pine bark extract lies in its high proanthocyanidin content. Free radicals inflict damage on capillaries through two mechanisms:

Inactivating a compound called 1-antitripsin, responsible for restraining enzymes that break down collagen, elastin, and hyaluronic acid.
Turning the fats in cell membranes rancid through lipid peroxidation.

Proanthocyanidins play a protective role by neutralizing specific types of free radicals that pose a threat to 1-antitripsin and lipids. They may also directly inhibit damaging enzymes. Collagen, elastin, and hyaluronic acid constitute a significant portion of the inner wall and supporting matrix of capillaries. When these components are in good condition, capillaries stretch to allow red blood cells through tight spaces while preventing fluid leakage.

Proanthocyanidins exhibit a notable tendency to accumulate in tissues rich in glycosaminoglycans, such as capillary walls and skin, possibly extending to cartilage and synovial fluid. At high concentrations (250 μg/ml), they show antimutagenic effects in vitro. Proanthocyanidins, also known as leucoanthocyanidins and pycnogenols, belong to the polyphenol family, a type of bioflavonoid. They surpass vitamin E by at least 15 to 25 times in neutralizing iron and reactive oxygen species/free radicals attacking lipids.

Grape seed extract is utilized for its ability to combat free radicals and address various conditions linked to capillary health and permeability. It synergizes with vitamin C, enhancing its potency and rapid absorption when used in conjunction with proanthocyanidins.

Proanthocyanidins in grape seeds demonstrate anti-inflammatory, antiarthritic, and antiallergic activities. They contribute to preventing skin aging, scavenging oxygen free radicals, and inhibiting the damaging effects of UV radiation from sunlight. Furthermore, they form bonds with collagen, a crucial protein in the body found in skin, gums, bones, teeth, hair, and other tissues.

Proanthocyanidins are recommended for conditions such as poor distribution of microcirculatory blood flow in the brain and Cardio Health, altered capillary fragility and permeability (in diabetes mellitus), chronic arterial/venous insufficiency in the extremities, altered platelet aggregation, breakdown in the elastic fibers of capillaries due to free-radical and enzyme action, microangiopathy of the retina, edema of the lymph nodes, varicose veins, cumulative effects of aging, and reducing the risk of degenerative diseases.