Designs For Health Metabolic Synergy 120 Capsules

Metabolic Synergy is a comprehensive formula designed to offer intensive metabolic Aid, featuring a diverse range of vitamins, minerals, and additional compounds to encourage healthy blood glucose metabolism and provide antioxidant Aid. This formulation aids in the efficient conversion of carbohydrates into energy, potentially contributing to the maintenance of normal blood glucose metabolism.

Tocotrienols: Delivered as DeltaGold, a tocopherol-free blend of gamma- and delta-tocotrienols sourced from annatto. Tocotrienols exhibit specific antioxidant activity and unique benefits distinct from tocopherols. (Refer to the tocotrienols white paper and Annatto-E tech sheet for an in-depth discussion on tocotrienol research and tocopherol limitations.) Tocotrienols are not readily available in common Nutrition Plans, and their absorption is hindered by concurrent tocopherol consumption. Therefore, this formula excludes tocopherols, as they are easily obtained from nuts, seeds, avocado, various vegetable oils, and numerous animal foods. This also creates an opportunity to supplement concurrently with highly beneficial doses of tocotrienols from Annatto-E 150/300, as tocopherols may impede their transportation to tissues.

Carnosine (β-alanyl-l-histidine): A dipeptide with antioxidant and chelating roles. Daily Nutrition Planary intake of carnosine ranges from 50–250 mg, while this formula provides 250 mg carnosine, totaling 500 mg when added to a healthy Nutrition Plan. In Cardio Health failure patients, supplementation with 500 mg/day of carnosine for 6 months led to improved physical performance, enhanced quality of life, and a trend towards increased end-diastolic volume. Reviews suggest that doses in the range of 1–2 g/day significantly reduce insulin, glycated hemoglobin, and insulin resistance, with some studies showing improved cognitive function. Additionally, carnosine acts as an antioxidant and heavy metal chelator, demonstrating protective effects against tissue glycation.

Taurine: An amino acid present ubiquitously in all mammalian tissues but absent in plant foods. Despite being synthesized from methionine and cysteine, human biosynthetic capacity is low, rendering taurine a conditionally essential amino acid. Animal and human studies indicate various biological actions of taurine, including antioxidation, ion movement modulation, osmoregulation, neurotransmitter modulation, and bile acid conjugation. Clinical trials in type 1 diabetics demonstrated improved carbohydrate metabolism, decreased blood triglycerides, and enhanced endothelial function following taurine supplementation.

R-Lipoic acid: A naturally occurring compound in plants and animals, acting as a fat- and water-soluble antioxidant in humans. This formula provides 100 mg R-lipoic acid, equivalent to the R-lipoic acid levels obtained from supplementing with 200 mg alpha-lipoic acid (R/S). The standalone R-lipoic acid is likely more clinically effective than the S-isomer-containing alpha-lipoic acid, as the S-isomer competes for docking on mitochondrial enzymes and has inhibitory actions. Reviews suggest doses of 300, 600, or 1200 mg for various health benefits, including normalizing glucose metabolism, lipid profile, inflammation, blood pressure, and endothelial function.

RATIONALE FOR SETTING INGREDIENT LEVELS IN METABOLIC SYNERGY

Metabolic Synergy supplies nutrients often insufficient in average Nutrition Plans, guided by criteria beyond RDAs and AIs. The values consider US average nutrient intakes, upper tolerable levels, and principles of evolutionary biology. Vitamin B levels are approximately 100% higher than in Twice Daily Multi to provide intense metabolic Aid. Folate, B12, niacin, vitamin C, vitamin A, and vitamin D levels are set based on average intakes, bioavailability, UL, and evolutionary Nutrition Planary principles. Chelated minerals are included for enhanced absorption, while magnesium, zinc, manganese, molybdenum, chromium, iodine, and selenium levels align with Paleo-style Nutrition Plans and nutritional recommendations.

For individualized supplementation, consider incorporating other Designs for Health formulas such as Sensitol for hyperinsulinemia or PCOS, Chromium Synergy for additional Aid, and antioxidants from PaleoGreens or PaleoReds. Tricobalamin, L-5-MTHF, or Homocysteine Supreme can provide extra B12 and/or folate.