Get exclusive offers, free shipping events & more
Track your orders, View your order history and much more. Start a FREE account today!
All information submitted is encrypted
Add $59.97 to your cart to qualify for FREE SHIPPING!.
You have no items in your shopping cart.
Add your review and earn 10 reward points.
Prices in Canadian Dollars
Sign up for price alert
SAMe 400 is s-adenosyl-L-methionine (SAMe), a key biological factor that drives a wide variety of essential biochemical reactions, including the methylation of DNA, catecholamine neurotransmitters (brain messenger-molecules), phospholipids, hormones, and chondrocytes (cartilage-forming cells). Research supports SAMe’s ability to support healthy mood function and helps relieve osteoarthritic pain.
S-Adenosyl-L-Methionine (SAMe) is a methyl group donor that supports the methylation cycle which is essential for health. Methylation is essential for ridding the body of certain toxins, and those with chronic liver disorders cannot produce adequate levels of SAMe.
SAMe’s effectiveness to support a balanced mood is demonstrated by many clinical studies. SAMe is so effective for boosting a low mood that it is legally registered as a prescription drug in several European countries for mood balance. One study showed that SAMe was as effective as a common prescription medication for mood. SAMe may help boost serotonin, dopamine and melatonin levels in the brain, low levels of which are commonly associated with mood imbalances such as anxiety and depression. SAMe has also been found to support joint health in osteoarthritis patients as effectively as a popular COX-2 inhibitor drug by reducing inflammation and protecting joint tissue from degradation.
AOR introduced the first SAMe supplement to Canada in 2000. SAMe is best known for helping to elevate low mood, but can also provide relief in osteoarthritis and support the methylation cycle. SAMe can provide mood support, benefit those suffering from osteoarthritis, and is essential for those with liver disorders to maintain good health. AOR’s SAMe 400 provides an effective dosage and a stable form of this valuable compound in an enteric coated tablet for maximum effectiveness.
that no ingredients not listed on the label have been added to the product. Contains no gluten, nuts, peanuts, sesame seeds, sulphites, mustard or dairy.
Take 2 or 3 tablets daily on an empty stomach, or as directed by a qualified health care practitioner. Use for a minimum of 4 weeks to see beneficial effects for osteoarthritic pain, and a minimum of 2 weeks for mood support.
Do not take at night since this product may cause anxiety, restlessness and insomnia. Consult with a health care practitioner prior to use if you are pregnant or breastfeeding, suffer from depression or are taking medications which may influence serotonin levels (e.g. antidepressants).
S-Adenosyl-L-Methioinine (SAMe) Disulfate Tosylate
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
I can't comment on whether this is 'working' but the product seems to be high quality and well packaged. Arrived quickly and in good condition.
This product is great, helps very much with mood swings. Skip buying takeout coffee and spend your money and something that is good for you!!
I use this product for depression and wouldn't be without it.
I searched for a SAME supplement without Malitol and in a blister package. I kept coming back to AOR brand. I have not been using it long enough to notice a difference. However there has been no tummy troubles like other have said can be associated with SAMe. This can be because of better quality product or no Malitol in the ingredients.
This has helped my husband tremendously with his S.A.D. We will definitely purchase as needed.
I find that SAMe ( in the AOR metallic foil blister pack), in combination with Curcumin (AOR) is the only thing that brings relief for my osteoarthritis. I have been taking these supplements for about three years now, and my osteoarthritis pain symptoms have virtually disappeared. A couple of other sufferers that I have convinced to try SAMe (without the curcumin) have reported the same results: they are thrilled with the way SAMe has made their pain "go away". I cannot recommend this product more highly for the relief of pain associatied with osteoarthritis.
SAMe is a very powerful and effective supplement for moods (anxiety, depression, stress). This is a serious supplement and you should talk to a health care provider if you intend on taking it for long term (ie: 6 months or more). However it is very expensive in Canada. If you cannot afford it try 5-htp or St. Johns Wort which work almost as good but at a cheaper price. Note: SAMe can raise homocysteine levels (which is not good for the heart) if taken at high does for a long duration. However, this can be offset by taking a Vitamin B complex daily which lowers homocysteine level.
I just started and was told 4-6 weeks is where I will see the benefits. I'm taking this 2x a day on an empty stomach, for my knee.
You Save 20%
You Save 15%
You Save 13%
You Save 14%
View Price In Cart