GENERAL INFORMATION
Calcium is a major mineral in the body that is perhaps most well known for its role in the formation and maintenance of strong, healthy bones and tooth enamel. Although the majority of calcium in the body is found stored in the bones and teeth, a small amount is also found in the bloodstream. Calcium in the blood has many important roles to play: it transports nutrients across cell membranes; produces hormones and enzymes involved in digestion and metabolism; is involved in nerve cell communication; promotes blood clotting and wound healing; and assists with muscle contractions. Calcium is an essential nutrient throughout the lifespan, but it is particularly important for growing children and adolescents to help establish adequate bone mass for maintaining strong bones throughout life.
Although only a small amount of calcium is found in the bloodstream, the body keeps blood levels of calcium tightly regulated. If there is inadequate calcium in the bloodstream, bone resorption (breakdown) will occur in order to draw calcium from the bones into the blood. Over many years, this condition can lead to the development of osteoporosis, a disease characterized by brittle and weak bones, which increases the risk of hip and vertebrae fractures as well as spinal deformities and loss of height. Osteoporosis generally strikes both men and women in later life, though it is a particular concern for post-menopausal women. The risk of osteoporosis increases when the diet does not provide adequate calcium. Regular calcium supplementation along with weight-bearing exercises can help prevent bone resorption and osteoporosis to reduce the risk of fractures later in life.
New scientific evidence shows that calcium plays many other important roles in the body. This mineral has been shown to support the health of the gastrointestinal tract by reducing the irritating effects of bile acids and fatty acids on the lower colon. Calcium is also thought to play a role in helping to reduce high blood pressure. By allowing the muscles to contract and relax, adequate calcium ensures that the heart and blood vessels function normally.
Other research indicates that calcium can help relieve symptoms of pre-menstrual syndrome (PMS), heartburn, and insomnia. Symptoms of PMS include irritability, mood swings, and depression. These symptoms have been attributed to several factors, one of which is hormonal imbalances caused by insufficient calcium. A regular calcium supplement may prevent symptoms of PMS, and reduce the severity of these symptoms when they do occur. Calcium is also thought to help alleviate insomnia in some individuals.
Approximately half of the magnesium in the body is found in the bones and it is an essential nutrient to keep them strong and healthy. Magnesium also plays an important role in maintaining the function of nerves and regulating muscle relaxation. A deficiency in magnesium is associated with the occurrence of muscle spasms, tremors and convulsion. Low magnesium levels have also been associated with psychiatric problems such as depression and schizophrenia.
Calcium and magnesium work together in the body to enhance each other’s absorption and utilization. The calcium:magnesium ratio should be 2:1 as found in Jamieson’s supplements, in order to prevent any adverse gastrointestinal effects that can occur when these minerals are taken in equal proportions. Both of these minerals are essential factors in the formation and maintenance of healthy bones, but they also play an important role in the contraction and relaxation of muscles, including the heart. When calcium flows into the muscle tissue cells they contract. When calcium leaves, magnesium replaces it and the muscle relaxes. They also work together to normalize the muscle tone of blood vessels.
Jamieson’s Mega CalTM Calcium Magnesium is formulated from natural sources and is pharmaceutically tested to guarantee full potency and absolute clinical purity.
What makes Mega CalTM Calcium Magnesium from Jamieson Laboratories different…and why does that difference mean better?
1) Magnesium and calcium work together to enhance each other’s absorption and utilization. A 2:1 formula of calcium to magnesium ensures maximal calcium absorption and prevents adverse gastrointestinal side effects.
2) Contains calcium from a highly absorbable natural complex, including carbonate and calcium bound to Krebs cycle intermediates, including citrate, fumarate, malate, succinate, and glutamate. The Krebs cycle is an energy producing system in the body’s cells. The intermediates derived from this process are already ionized, soluble, and non-toxic. This unique proprietary blend of calcium sources is therefore highly bioavailable, and also helps to enhance the absorption of other minerals in the body.
3) It is also formulated using a highly absorbable natural complex of five magnesium sources including citrate, fumarate, malate, succinate and glutamate.
INGREDIENT INFORMATION
Available as 100 caplets.
Each caplet contains:
Elemental Calcium…………………………………333 mg
From a microbound formula of carbonate and Krebs cycle sources of citrate, fumarate, malate, succinate and glutamate.
Elemental Magnesium……………………………..167 mg
From oxide and Krebs cycle sources of citrate, fumarate, malate, succinate and glutamate.
EXCIPIENTS
Cellulose, Croscarmellose Sodium, Vegetable Distilled Monoglycerides, Purified Stearic Acid, Vegetable Magnesium Stearate, Silicon Dioxide, Hypromellose, Titanium Dioxide, Hydroxypropylcellulose, Polyethylene Glycol, Carnauba Wax, Polysorbate 80.
DOSAGE
Adults - Take 1 caplet 3 times daily with meals. Keep in a cool, dry place away from children.
INDICATED BENEFITS
• Maintains strong bones and healthy teeth
• Helps prevent osteoporosis to reduce the risk of fractures later in life
• May help reduce high blood pressure
• Plays a role in relieving symptoms of PMS
• Helps alleviate insomnia
• Supports colon health
• Good for adolescents and post-menopausal women
Aids function of nerves and muscles, including regulation of normal heart rhythm
Maintains steady metabolism
Conducts nerve impulses
NUTRIENT INTERACTIONS
Drug Interactions
Calcium and magnesium can interfere with tetracycline antibiotics and calcium channel blockers. Consult your physician before use if you are taking any thiazide diuretics, as these can cause extremely high (potentially toxic) levels of calcium in the body. Magnesium can increase levels of diuretics in the body.
Nutrient Depletions
Excess calcium can impair the absorption of the minerals iron and zinc.
Calcium and/or magnesium may interact with or be depleted by corticosteroids, bronchodilators, anti-osteoporotics, cholesterol-reducing medications, anti-gout medications, anti-fungals, immunosuppressants, anti-malarial drugs, anti-tuberculosis drugs, oral contraceptives, biguanides, sulfonylureas, and sulfonamides.
Foods high in phosphorus (animal protein and soft drinks) promote urinary loss of calcium. High consumption of caffeine, and excess dietary fat and fibre can inhibit calcium absorption.
Supportive Interactions
Vitamin D enhances calcium absorption. Ensure that you are getting at least 400 IU of vitamin D each day for optimal calcium absorption. Garlic supplements along with calcium may help reduce high blood pressure.
WARNINGS AND PRECAUTIONS
Individuals with kidney or thyroid disorders should consult a healthcare practitioner before use.
Take calcium and magnesium supplements two hours after bisphosphonates.
TOXICITY, ADVERSE REACTIONS, AND SIDE EFFECTS
Calcium carbonate may cause symptoms of gas, bloating, or constipation. If this occurs, switch to calcium citrate. Excess calcium can contribute to the development of kidneys stones, and may cause calcium deposits in the body.
If you experience abdominal pain, appetite loss, diarrhea, irregular heartbeat, mood or mental changes, nausea, tiredness, weakness, discomfort urinating, or vomiting, discontinue use and contact a physician.
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